Welcome to the LevyLab

Understanding modern human disease is only possible from the perspective of the metagenome, the entirety of all microbial genomes associated with the human body. We study the interface between the host and its microbiome in the gastrointestinal tract, with a particular focus on microbiome-derived metabolites. We are a newly opened lab at the Microbiology Department, University of Pennsylvania.

The intestinal epithelium

We study new epithelial cell function in host-microbiome interactions


We investigate the role of microbiota-derived metabolites in host health and disease

Innate immunity

We explore new features of the intestinal innate immune response to the microbiota

The lab has opened in March 2018

We are excited to build a state-of-the-art environment for the study of host-microbiome interactions and epithelial cell biology. We are currently looking for highly talented and motivated scientists at all…

New review in Nature Reviews Immunology

Throughout the past century, we have seen the emergence of a large number of multifactorial diseases, including inflammatory, autoimmune, metabolic, neoplastic and neurodegenerative diseases, many of which have been recently…

New paper on epithelial-microbiota interactions in Cell

The intestinal microbiota undergoes diurnal compositional and functional oscillations that affect metabolic homeostasis, but the mechanisms by which the rhythmic microbiota influences host circadian activity remain elusive. Using integrated multi-omics…

We are currently recruiting highly talented and motivated individuals to join our lab!