The intestinal host-microbiome interface comprises one of the most complex ecosystems on Earth. The bacterial, viral, and eukaryotic microbiome influences many aspects of host physiology, but at the same time needs to be tightly controlled in its colonization by the intestinal epithelium. We study this interface using three complementary fields of research.
We are exploring new functions of the intestinal epithelium in the maintenance of host-microbiota mutualism. A particular focus is on the integration of cellular function with the regulation of intestinal colonization by bacteria, viruses, and eukaryotes.
We are investigating the role of dietary and microbiome-derived metabolites as regulators of host immunity and metabolism. Of particular interest is the role of metabolites in inflammatory, infectious, and neoplastic disease.
We are studying new modalities of innate immunity in classical and non-classical immune cells. We aim to decipher the integration of immune signaling pathways into cellular function.