Serotonin reduction in post-acute sequelae of viral infection Post-acute sequelae of COVID-19 (PASC, “Long COVID”) pose a significant global health challenge. The pathophysiology is unknown, and no effective treatments have…
The enteric nervous system relays psychological stress to intestinal inflammation Mental health profoundly impacts inflammatory responses in the body. This is particularly apparent in inflammatory bowel disease (IBD), in which…
Preterm birth is associated with xenobiotics and predicted by the vaginal metabolome Spontaneous preterm birth (sPTB) is a leading cause of maternal and neonatal morbidity and mortality, yet its prevention…
β-Hydroxybutyrate suppresses colorectal cancer Colorectal cancer (CRC) is among the most frequent forms of cancer, and new strategies for its prevention and therapy are urgently needed1. Here we identify a…
Dysbiosis and the immune system Throughout the past century, we have seen the emergence of a large number of multifactorial diseases, including inflammatory, autoimmune, metabolic, neoplastic and neurodegenerative diseases, many…
Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations The intestinal microbiota undergoes diurnal compositional and functional oscillations that affect metabolic homeostasis, but the mechanisms by which the rhythmic microbiota influences host…
The microbiome and innate immunity The intestinal microbiome is a signalling hub that integrates environmental inputs, such as diet, with genetic and immune signals to affect the host’s metabolism, immunity…
