Citrobacter rodentium Relies on Commensals for Colonization of the Colonic Mucosa We investigated the role of commensals at the peak of infection with the colonic mouse pathogen Citrobacter rodentium. Bioluminescent and…

Quantitative analysis of protein-protein interactions and post-translational modifications in rare immune populations In spite of recent advances in proteomics, quantitative analyses of protein-protein interactions (PPIs) or post-translational modifications (PTMs) in…

The Role of the Immune System in Metabolic Health and Disease In addition to the immune system’s traditional roles of conferring anti-infectious and anti-neoplastic protection, it has been recently implicated…

NLRP6: A Multifaceted Innate Immune Sensor NLRP6, a member of the nucleotide-binding domain, leucine-rich repeat-containing (NLR) innate immune receptor family, regulates inflammation and host defense against microorganisms. Similar to other…

Microbiome-Modulated Metabolites at the Interface of Host Immunity The mammalian gastrointestinal tract and associated mucosal immune system harbor a large repertoire of metabolites of prokaryotic and eukaryotic origin that play…

Microbiome, metabolites and host immunity In the intestine, the microbial genomes and repertoire of biochemical reactions outnumber those of the host and significantly contribute to many aspects of the host’s…